Article

DNA Methylation Ageing Atlas Across 17 Human Tissues

2025-07-24

Abstract excerpt

Aging involves widespread epigenetic remodeling across tissues, yet the nature and consistency of these changes remain unclear. We conducted a meta-analysis of more than 15,000 human methylomes spanning 17 tissues, identifying both conserved and tissue-specific aging signatures. We examined linear changes via differentially methylated positions, variability shifts via variably methylated positions, and Shannon-ent...

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Literature Corpus work: 8ddab9ca-b69f-5291-8c98-3cfa4e3205f8
DOI: 10.1101/2025.07.21.665830

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