DNA Methylation Ageing Atlas Across 17 Human Tissues

Abstract excerpt

<title>Abstract</title> <p>Aging involves widespread epigenetic remodeling across tissues, yet the nature and consistency of these changes remain unclear. We conducted a meta-analysis of more than 15,000 human methylomes spanning 17 tissues, identifying both conserved and tissue-specific aging signatures. We examined linear changes via differentially methylated positions, variability shifts via variably methylate...

Topics

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• Epigenetics and DNA Methylation
• Birth, Development, and Health
• Genetics, Aging, and Longevity in Model Organisms
• Genetics and Neurodevelopmental Disorders

Identifiers and source

Literature Corpus work

9b0c8298-7cbb-5e7b-8f52-527f7f99a181

DOI

10.21203/rs.3.rs-7184037/v1