Article

Alignment-based protein mutational landscape prediction: doing more with less

2022-12-15

Abstract excerpt

The wealth of genomic data has boosted the development of computational methods predicting the phenotypic outcomes of missense variants. The most accurate ones exploit multiple sequence alignments, which can be costly to generate. Recent efforts for democratizing protein structure prediction have overcome this bottleneck by leveraging the fast homology search of MMseqs2. Here, we show the usefulness of this strate...

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Literature Corpus work: d8273ae9-1425-52b2-9506-3131e2e64563
DOI: 10.1101/2022.12.13.520259

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