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Article

ADDRESS: A Database of Disease-associated Human Variants Incorporating Protein Structure and Folding Stabilities.

Journal of molecular biology - 28 May 2021

Woodard Jaie, Zhang Chengxin, Zhang Yang

Abstract excerpt

Numerous human diseases are caused by mutations in genomic sequences. Since amino acid changes affect protein function through mechanisms often predictable from protein structure, the integration of structural and sequence data enables us to estimate with greater accuracy whether and how a given mutation will lead to disease. Publicly available annotated databases enable hypothesis assessment and benchmarking of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33539887
DOI: 10.1016/j.jmb.2021.166840
PMCID: PMC8119349

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