Article

ULK1 drives NDP52-mediated selective autophagic degradation of MHC-I to promote immune evasion in HPV-positive head and neck cancer

2026-03-18

Abstract excerpt

<h4>ABSTRACT</h4> Antigen presentation by major histocompatibility complex class I (MHC-I) is critical for tumor cell killing by CD8 + T cells. Accordingly, tumor cells downregulate MHC-I expression through multiple mechanisms, thereby evading the immune response. Importantly, lower levels of MHC-I are associated with poor responses to immune checkpoint inhibitor therapy. Our recent study has shown that the huma...

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Literature Corpus work: d82215e0-be0b-59f5-9318-ee7ada8e403e
DOI: 10.64898/2026.03.14.711071

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