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Article

Neddylation as a target in PIK3CA-mutated head and neck cancer.

Biochemical and biophysical research communications - 20 May 2025

Naara Shorook, Cui Zhibin, Izgutdina Adila, VanLandingham Nathan K, Nazarenko Andrew, Woerner Liam C, Hua Fu Becky Xu, Gilbert Luke A, Johnson Daniel E, Grandis Jennifer R

Abstract excerpt

PIK3CA encodes the catalytic subunit of phosphoinositide 3-kinase (PI3K) enzyme and is the most commonly mutated oncogene in head and neck squamous cell carcinoma (HNSCC). This study aimed to identify potential therapeutic targets in HNSCC harboring mutant PIK3CA. We used CRISPR interference (CRISPRi)-based genome-wide screening methodology to reveal targetable genetic dependencies in PIK3CA-mutated HNSCC....

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Topics

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Share to Cell Line, Tumor
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PIK3CA gene

Share to Head and Neck Neoplasms

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Share to Squamous Cell Carcinoma of Head and Neck

Share to Ubiquitin-Activating Enzymes

Source

Open in PubMed Open full text

Identifiers

PMID: 40154000
DOI: 10.1016/j.bbrc.2025.151703
PMCID: PMC12036330

Genes

PIK3CA
NEDD8
NAE1
UBA3
USP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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