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Article

Human Papilloma Virus Specific Immunogenicity and Dysfunction of CD8+ T Cells in Head and Neck Cancer.

Cancer research - 1 Nov 2018

Krishna Sri, Ulrich Peaches, Wilson Eric, Parikh Falguni, Narang Pooja, Yang Shanshan, Read Amelia K, Kim-Schulze Seunghee, Park Jin G, Posner Marshall, Wilson Sayres Melissa A, Sikora Andrew, Anderson Karen S

Abstract excerpt

Human papillomavirus subtype 16 (HPV16) is the primary cause of an increasing number of head and neck squamous cell carcinomas (HNSCC), providing strong rationale for T-cell immune therapies against HPV+ HNSCC. Here we assess immunogenicity of HPV16-specific CD8+ T cells (CTL) and characterize HPV-specific mechanisms of T-cell dysfunction. We identified 16 strong and 29 moderately immunogenic CTL-epitopes from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30154146
DOI: 10.1158/0008-5472.CAN-18-0163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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