Back to search

Article

Collective fluctuations underlying nanobody inhibitory activity targeting <i>B. anthracis</i> S-layers revealed by multiscale simulations

2026-07-01

Abstract excerpt

Nanobodies (Nbs) that depolymerize bacterial surface-layers (S-layers) offer a route to antivirulence therapeutics, but their mechanisms have been difficult to infer from binding structures alone. In B. anthracis, several Nbs bind to Sap, the S-layer protein that assembles into a paracrystalline lattice surrounding the cell. Despite similar binding poses and sequences, only a subset of these (“inhibitory”) Nbs in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d80cf091-15fd-5c74-bcb5-b214be385654
DOI
10.64898/2026.06.26.734918
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Collective fluctuations underlying nanobody inhibitory activity targeting <i>B. anthracis</i> S-layers revealed by multiscale simulationsDOI 10.64898/2026.06.26.734918
S-layers: The Proteinaceous Multifunctional Armors of Gram-Positive PathogensSemantic proximity
Cryo-ET of a human GBP coatomer governing cell-autonomous innate immunity to infectionSemantic proximity
Microscale spatial fragmentation promotes bacterial survival under antibioticsSemantic proximity
Sequence-encoded conformational biases shape self-assembly modes of intrinsically disordered proteinsSemantic proximity
<i>In situ</i> Architecture of the Tad Pilus Machine in <i>Caulobacter crescentus</i>Semantic proximity
Conformational stability of the bacterial adhesin, FimH, with an inactivating mutation.Semantic proximity
Amyloid-Like β-Aggregates as Force-Sensitive Switches in Fungal Biofilms and InfectionsSemantic proximity
Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperonesSemantic proximity
Multiple stiffening effects of nanoscale knobs on human red blood cells infected with <i>Plasmodium falciparum</i> malaria parasiteSemantic proximity
Active Learning–Guided Peptide Design for Modulating Condensate Properties upon RecruitmentSemantic proximity
High-order combination effects and biological robustness.Semantic proximity
Irreversibility and symmetry breaking in the creation and annihilation of defects in active living matterSemantic proximity
Select a neighboring publication to make it the new centre.