Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-order combination effects and biological robustness.

Molecular systems biology - 1 Jan 2008

Lehár Joseph, Krueger Andrew, Zimmermann Grant, Borisy Alexis

Abstract excerpt

Biological systems are robust, in that they can maintain stable phenotypes under varying conditions or attacks. Biological systems are also complex, being organized into many functional modules that communicate through interlocking pathways and feedback mechanisms. In these systems, robustness and complexity are linked because both qualities arise from the same underlying mechanisms. When perturbed by multiple...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Feedback, Physiological
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Homeostasis

Share to Models, Genetic

Share to Mutation

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 18682705
DOI: 10.1038/msb.2008.51
PMCID: PMC2538911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-order combination effects and biological robustness.PMID 18682705Read ↗

Simple biological controllers drive the evolution of soft modes.Semantic proximity Read ↗

Robustness and lethality in multilayer biological molecular networksSemantic proximity Read ↗

Systematic discovery of drug interaction mechanisms.Semantic proximity Read ↗

The theory of biological robustness and its implication in cancer.Semantic proximity Read ↗

Stability, robustness, and containment: preparing synthetic biology for real-world deployment.Semantic proximity Read ↗

Anti-Windup Protection Circuits for Biomolecular Integral ControllersSemantic proximity Read ↗

Predicting effects of structural stress in a genome-reduced model bacterial metabolism.Semantic proximity Read ↗

Controllability in Multiplex Biological Networks withInsights into Virus-Related DiseasesSemantic proximity Read ↗

Structural hormesis in protein aggregation: A minimal mechanistic modelSemantic proximity Read ↗

High-Dimensional Mutant and Modular Thermodynamic Cycles, Molecular Switching, and Free Energy Transduction.Semantic proximity Read ↗

Exploiting the pathway structure of metabolism to reveal high-order epistasis.Semantic proximity Read ↗

Environmental flexibility does not explain metabolic robustness.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.