Article

De Novo Sequencing of Antibody Light Chain Proteoforms from Patients with Multiple Myeloma

2021-05-06

Abstract excerpt

In multiple myeloma diseases, monoclonal immunoglobulin light chains (LC) are abundantly produced, with the consequence in some cases to form deposits affecting various organs, such as kidney, while in other cases to remain soluble up to concentrations of several g.L -1 in plasma. The exact factors crucial for the solubility of light chains are poorly understood, but it can be hypothesized that their amino acid s...

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Literature Corpus work: d7fe3f4c-28f7-5362-946d-bbada47f1e09
DOI: 10.26434/chemrxiv.14541711.v1

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