Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors.

Molecular cancer - 16 May 2011

Stehr Henning, Jang Seon-Hi J, Duarte José M, Wierling Christoph, Lehrach Hans, Lappe Michael, Lange Bodo M H

Abstract excerpt

BACKGROUND: Current large-scale cancer sequencing projects have identified large numbers of somatic mutations covering an increasing number of different cancer tissues and patients. However, the characterization of these mutations at the structural and functional level remains a challenge. RESULTS: We present results from an analysis of the structural impact of frequent missense cancer mutations using an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Genetic
Share to Molecular Sequence Annotation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Structure

Share to Mutation, Missense

Share to Neoplasms

Share to Oncogene Proteins

Share to Protein Stability

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21575214
DOI: 10.1186/1476-4598-10-54
PMCID: PMC3123651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors.PMID 21575214Read ↗

Protein structural context of cancer mutations reveals molecular mechanisms and identifies novel candidate driver genesSemantic proximity Read ↗

Protein structural context of cancer mutations reveals molecular mechanisms and candidate driver genes.Semantic proximity Read ↗

Structural and functional impact of cancer-related missense somatic mutations.Semantic proximity Read ↗

Mutational patterns in oncogenes and tumour suppressors.Semantic proximity Read ↗

Identification and analysis of mutational hotspots in oncogenes and tumour suppressors.Semantic proximity Read ↗

Exome-Scale Discovery of Hotspot Mutation Regions in Human Cancer Using 3D Protein Structure.Semantic proximity Read ↗

Gain of function of mutant p53: R282W on the peak?Semantic proximity Read ↗

Systematic characterization of pan-cancer mutation clusters.Semantic proximity Read ↗

The mutational landscape of phosphorylation signaling in cancer.Semantic proximity Read ↗

Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysisSemantic proximity Read ↗

Gain and loss of phosphorylation sites in human cancer.Semantic proximity Read ↗

Structural and functional implications of p53 missense cancer mutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.