Article

Clinically defined mutations in <i>MEN1</i> alter its tumor-suppressive function through increased menin turnover

2022-12-20

Abstract excerpt

Loss of the tumor suppressor protein menin is a critical event underlying the formation of neuroendocrine tumors (NETs) in hormone-expressing tissues including gastrinomas. While aberrant expression of menin impairs its tumor suppression, few studies explore the structure– function relationship of clinical Multiple Endocrine Neoplasia, type 1 ( MEN1 ) mutations in the absence of a complete loss of heterozygosity...

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Literature Corpus work: d77a5bad-6822-5c17-bd07-e7365831925e
DOI: 10.1101/2022.12.20.521296

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