Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Menin Missense Mutants Encoded by the MEN1 Gene that Are Targeted to the Proteasome: Restoration of Expression and Activity by CHIP siRNA

17 Nov 2011

Abstract excerpt

CONTEXT: In multiple endocrine neoplasia type 1 (MEN1) characterized by tumors of parathyroid, enteropancreas, and anterior pituitary, missense mutations in the MEN1 gene product, menin, occur in a subset of cases. The mutant proteins are degraded by the proteasome. However, whether their expression and activity can be restored is not known. OBJECTIVE: Our objective was to functionally characterize a panel of 16...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroendocrine Tumor Research Advances
Share to Thyroid Cancer Diagnosis and Treatment
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22090276
DOI: 10.1210/jc.2011-0241

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Menin Missense Mutants Encoded by the MEN1 Gene that Are Targeted to the Proteasome: Restoration of Expression and Activity by CHIP siRNAPMID 22090276Read ↗

Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway.Semantic proximity Read ↗

Distinct clinical phenotypes in a family with a novel truncating MEN1 frameshift mutation.Semantic proximity Read ↗

Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the geneSemantic proximity Read ↗

The future: genetics advances in MEN1 therapeutic approaches and management strategiesSemantic proximity Read ↗

Correlation of mutant menin stability with clinical expression of multiple endocrine neoplasia type 1 and its incomplete forms.Semantic proximity Read ↗

MEN1 gene and its mutations: basic and clinical implications.Semantic proximity Read ↗

Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicitySemantic proximity Read ↗

MENIN loss as a tissue-specific driver of tumorigenesis.Semantic proximity Read ↗

The MEN1 gene and associated diseases: an update.Semantic proximity Read ↗

Clinically defined mutations in <i>MEN1</i> alter its tumor-suppressive function through increased menin turnoverSemantic proximity Read ↗

Twenty years of menin: emerging opportunities for restoration of transcriptional regulation in MEN1Semantic proximity Read ↗

Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.