Article

Nuclear exclusion of menin drives functional MEN1 deficiency in non-MEN1 prolactinomas: mouse models and human biopsies

2026-08-24

Abstract excerpt

<h4>ABSTRACT</h4> Prolactinomas, the most common secretory pituitary tumour subtype, frequently occur in patients with Multiple Endocrine Neoplasia type 1, caused by germline MEN1 mutations encoding menin. While menin loss is well established in MEN1-associated prolactinomas, its role in sporadic tumours remains unclear. We investigated menin expression, subcellular localization, and downstream signalling in two...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: a1795913-a3f4-5e39-b947-9b25310619bc
DOI: 10.64898/2026.08.19.745771

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Nuclear exclusion of menin drives functional MEN1 deficiency in non-MEN1 prolactinomas: mouse models and human biopsiesDOI 10.64898/2026.08.19.745771Read

Clinically defined mutations in <i>MEN1</i> alter its tumor-suppressive function through increased menin turnoverSemantic proximity Read

MENIN loss as a tissue-specific driver of tumorigenesis.Semantic proximity Read

Multiple Endocrine Neoplasia Type 1: Latest InsightsSemantic proximity Read

Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumoursSemantic proximity Read

The MEN1 gene and pituitary tumours.Semantic proximity Read

MEN1, MEN4, and Carney Complex: Pathology and Molecular GeneticsSemantic proximity Read

Thoracic and duodenopancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1: natural history and function of menin in tumorigenesisSemantic proximity Read

Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover.Semantic proximity Read

Review: multiple endocrine neoplasia type 1, sporadic neuroendocrine tumors, and MENIN.Semantic proximity Read

Differential expression of menin in sporadic pituitary adenomas.Semantic proximity Read

High incidence of mammary intraepithelial neoplasia development in Men1-disrupted murine mammary glands.Semantic proximity Read

Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1.Semantic proximity Read