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Article

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation.

Journal of inherited metabolic disease - 1 Oct 2010

Houten Sander Michel, Wanders Ronald J A

Abstract excerpt

Over the years, the mitochondrial fatty acid β-oxidation (FAO) pathway has been characterised at the biochemical level as well as the molecular biological level. FAO plays a pivotal role in energy homoeostasis, but it competes with glucose as the primary oxidative substrate. The mechanisms behind this so-called glucose-fatty acid cycle operate at the hormonal, transcriptional and biochemical levels. Inherited...

Topics

Animals
Disease Models, Animal
Energy Metabolism
Fatty Acids
Genotype
Homeostasis
Humans
Lipid Metabolism, Inborn Errors
Mice
Mitochondria
Mitochondrial Diseases
Oxidation-Reduction

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Identifiers

PMID: 20195903
DOI: 10.1007/s10545-010-9061-2
PMCID: PMC2950079

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