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Article

Identification of the hair cell soma-1 antigen, HCS-1, as otoferlin.

Journal of the Association for Research in Otolaryngology : JARO - 1 Dec 2010

Goodyear Richard J, Legan P Kevin, Christiansen Jeffrey R, Xia Bei, Korchagina Julia, Gale Jonathan E, Warchol Mark E, Corwin Jeffrey T, Richardson Guy P

Abstract excerpt

Hair cells, the mechanosensitive receptor cells of the inner ear, are critical for our senses of hearing and balance. The small number of these receptor cells in the inner ear has impeded the identification and characterization of proteins important for hair cell function. The binding specificity...

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Identifiers

PMID: 20809368
DOI: 10.1007/s10162-010-0231-6
PMCID: PMC2975885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20809368-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the hair cell soma-1 antigen, HCS-1, as otoferlin.PMID 20809368Read ↗

Otoferlin: a multi-C2 domain protein essential for hearing.Semantic proximity Read ↗

A missense mutation in the conserved C2B domain of otoferlin causes deafness in a new mouse model of DFNB9.Semantic proximity Read ↗

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearingSemantic proximity Read ↗

Zebrafish Models for the Mechanosensory Hair Cell Dysfunction in Usher Syndrome 3 Reveal That Clarin-1 Is an Essential Hair Bundle Protein.Semantic proximity Read ↗

Regionalized protein localization domains in the zebrafish hair cell kinociliumSemantic proximity Read ↗

Pejvakin, a Candidate Stereociliary Rootlet Protein, Regulates Hair Cell Function in a Cell-Autonomous Manner.Semantic proximity Read ↗

Usher protein functions in hair cells and photoreceptorsSemantic proximity Read ↗

A mutation in OTOF, encoding otoferlin, a FER-1-like protein, causes DFNB9, a nonsyndromic form of deafness.Semantic proximity Read ↗

Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cellsSemantic proximity Read ↗

Molecular Specializations Underlying Phenotypic Differences in Inner Ear Hair Cells of Zebrafish and MiceSemantic proximity Read ↗

Single-Cell Transcriptomic Profiling of the Zebrafish Inner Ear Reveals Molecularly Distinct Hair Cell and Supporting Cell SubtypesSemantic proximity Read ↗

The crystal structure of the C₂A domain of otoferlin reveals an unconventional top loop region.Semantic proximity Read ↗

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