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Article

Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Mar 2013

Jing Zhizi, Rutherford Mark A, Takago Hideki, Frank Thomas, Fejtova Anna, Khimich Darina, Moser Tobias, Strenzke Nicola

Abstract excerpt

Inner hair cells (IHCs) of the cochlea use ribbon synapses to transmit auditory information faithfully to spiral ganglion neurons (SGNs). In the present study, we used genetic disruption of the presynaptic scaffold protein bassoon in mice to manipulate the morphology and function of the IHC synapse. Although partial-deletion mutants lacking functional bassoon (Bsn(ΔEx4/5)) had a near-complete loss of ribbons from...

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Identifiers

PMID: 23467361
DOI: 10.1523/JNEUROSCI.3491-12.2013
PMCID: PMC6704940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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