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Article

Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis.

The EMBO journal - 3 Feb 2014

Wong Aaron B, Rutherford Mark A, Gabrielaitis Mantas, Pangrsic Tina, Göttfert Fabian, Frank Thomas, Michanski Susann, Hell Stefan, Wolf Fred, Wichmann Carolin, Moser Tobias

Abstract excerpt

Cochlear inner hair cells (IHCs) develop from pre-sensory pacemaker to sound transducer. Here, we report that this involves changes in structure and function of the ribbon synapses between IHCs and spiral ganglion neurons (SGNs) around hearing onset in mice. As synapses matured they changed from holding several small presynaptic active zones (AZs) and apposed postsynaptic densities (PSDs) to one large AZ/PSD...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24442635
DOI: 10.1002/embj.201387110
PMCID: PMC3989618

Genes

PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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