Analysis of patient data reveals novel cancer-relevant functions for GCN2/eIF2αK4

Abstract excerpt

Numerous studies have shown that high GCN2 levels correlate with poor survival in a number of cancers. GCN2 has been known for over thirty years as a stress-response kinase, which phosphorylates the translation-initiation factor eIF2α, and thereby contributes to reprogramming of translation. Here we performed correlation analyses of GCN2 expression and that of other genes in a patient-derived sample set of cervica...

Topics

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• Advanced Proteomics Techniques and Applications
• Amino Acids
• Mutation
• Neoplasms
• Peptidase Inhibition and Analysis
• Phosphorylation
• Protein Serine-Threonine Kinases
• RNA and protein synthesis mechanisms

Identifiers and source

Literature Corpus work

d70af18b-1d51-532f-ac17-232aa5c9ca34

DOI

10.1101/2025.03.18.643965