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Article

Genetic and biochemical evidence for yeast GCN2 protein kinase polymerization.

Gene - 27 May 1994

Diallinas G, Thireos G

Abstract excerpt

The GCN2 (general control kinase 2) protein is an eIF2-alpha (eukaryotic initiation factor alpha) kinase which mediates translational derepression of the yeast general control transcriptional activator, GCN4, upon amino-acid starvation. We isolated and characterized GCN2 mutations differentially affecting GCN2 function. Mutations mapping in, or close to, the ATP-binding site of the kinase moiety result in...

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Identifiers

PMID: 8200534
DOI: 10.1016/0378-1119(94)90599-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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