Article
Genetic and biochemical evidence for yeast GCN2 protein kinase polymerization.
Gene - 27 May 1994
Diallinas G, Thireos G
Abstract excerpt
The GCN2 (general control kinase 2) protein is an eIF2-alpha (eukaryotic initiation factor alpha) kinase which mediates translational derepression of the yeast general control transcriptional activator, GCN4, upon amino-acid starvation. We isolated and characterized GCN2 mutations differentially...
Topics
- Amino Acids
- Chromatography, Gel
- DNA Mutational Analysis
- DNA-Binding Proteins
- Eukaryotic Initiation Factor-2
- Fungal Proteins
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Mutation
- Peptide Initiation Factors
- Peptide Mapping
- Phosphorylation
- Protein Biosynthesis
- Protein Kinases
- Protein Serine-Threonine Kinases
- RNA, Messenger
- Repressor Proteins