Article

Malat1 regulates PMN-MDSC expansion and immunosuppression through p-STAT3 ubiquitination in sepsis

2023-07-14

Abstract excerpt

<title>Abstract</title> <p>Myeloid-derived suppressor cells (MDSCs) expand during sepsis and contribute to the development of persistent inflammation-immunosuppression-catabolism syndrome. However, the underlying mechanism remains unclear. Exploring the mechanisms of MDSCs generation may provide therapeutic targets for improving immune status in sepsis. Here, a sepsis mouse model is established by cecal ligation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 92e313ce-2db1-5e2b-8312-51f71b3f606b
DOI: 10.21203/rs.3.rs-3113553/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Malat1 regulates PMN-MDSC expansion and immunosuppression through p-STAT3 ubiquitination in sepsisDOI 10.21203/rs.3.rs-3113553/v1Read

Clinical Significance of MDSCs in Patients with SepsisSemantic proximity Read

microRNA-590-3p regulates inflammation and organ dysfunction in sepsis mouse model via the Syap1-mediated TGF-β/Smad signaling pathwaySemantic proximity Read

Cuproptosis-related gene signatures and immunological characterization in sepsis- associated acute lung injurySemantic proximity Read

The Role of m6A Methylation Genes in Predicting Poor Prognosis in Sepsis: Identifying Key Biomarkers and Therapeutic TargetsSemantic proximity Read

A Meta-Analysis of Whole Blood Transcriptome Reveals Association of Increased Neutrophil Activity and T cell Suppression in SepsisSemantic proximity Read

Global transcriptional regulation of STAT3- and MYC-mediated sepsis-induced ARDSSemantic proximity Read

Role of cellular senescence genes and Immune Infiltration in sepsis and sepsis-induced ARDS based on bioinformatics analysisSemantic proximity Read

SAMSN1 causes sepsis immunosuppression by inducing macrophages to express coinhibitory molecules that causes T cell exhaustion via KEAP1-NRF2 signalingSemantic proximity Read

exploring the molecular mechanism of sepsis comprehensively based on multi-omics analysisSemantic proximity Read

Identification of molecular diagnostic markers in sepsis-induced acute lung injurySemantic proximity Read

Revealing the regulatory mechanism of FSP1 and N4-acetylcytosine in sepsis-induced acute lung injury by integrating multi-omics dataSemantic proximity Read

Identification of key immune genes for sepsis-induced ARDS based on bioinformatics analysisSemantic proximity Read