Article

Genomic Fit and Environmental Mismatch: The Tradeoff Model of Polygenic Operating Range

2026-08-30

Abstract excerpt

Why do "harmless" common genetic variants trigger catastrophic failures under specific environmental stress?Moving beyond reductionist "one-variant-one-disease" paradigms, this monograph introduces the Tradeoff Model of Polygenic Operating Range. It reframes common polymorphisms (SNPs) as conditional modifiers of a system's collective buffering capacity within a dynamic environment.The paper introduces the mechani...

Identifiers and source

Literature Corpus work: d6ec47db-3ce4-5f65-963e-700e2d51628a
DOI: 10.5281/zenodo.22168271

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