Back to search

Article

The Sensitivity Threshold Model (STM): A Conceptual Framework for Integrating 22 Canonical Findings in Schizophrenia

2025-12-19

Abstract excerpt

The Sensitivity Threshold Model (STM) is a systems-level conceptual framework proposing that psychosis may emerge when the dynamic relation Sensitivity × Load > Capacity drives neural systems beyond stability thresholds. STM formalizes three core constructs: Sensitivity, defined as trait-level neural reactivity shaped by genetic, developmental, sensory, and pharmacological factors; Load, defined as the cumulati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
db9f919a-1c02-5ff9-b22e-8a9123479fd5
DOI
10.20944/preprints202512.1769.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The Sensitivity Threshold Model (STM): A Conceptual Framework for Integrating 22 Canonical Findings in SchizophreniaDOI 10.20944/preprints202512.1769.v1
A Constraint-Based Framework for Architectural Evaluation in Schizophrenia ResearchSemantic proximity
A novel precision medicine framework based on the excitation-inhibition imbalance model, for treatment of schizophrenia across the life spanSemantic proximity
Convergent Multimodal Evidence of Cortical Excitation-Inhibition Imbalance in PsychosisSemantic proximity
The stress-vulnerability model how does stress impact on mental illness at the level of the brain and what are the consequences?Semantic proximity
Systems biology of complex symptom profiles: capturing interactivity across behavior, brain and immune regulation.Semantic proximity
When Randomness Becomes Rigid: Dynamic Connectivity Entropy and Symptom-Linked Network Dysfunction in SchizophreniaSemantic proximity
Is criticality a unified set-point of brain function?Semantic proximity
Task-related Controllability of Functional Connectome During a Working Memory Task in Schizophrenia, Bipolar Disorder, and Major Depressive DisorderSemantic proximity
Uncovering the determinants of brain functioning, behavior and their interplay in the light of contextSemantic proximity
Psychometric archetypes reveal biological signatures of vulnerability, resilience, and future mental healthSemantic proximity
Linking Brain Entropy to Molecular and Cellular Architecture in PsychosisSemantic proximity
The Perfect Storm Framework: A Testable Multi-Hit Model Linking Connective Tissue Variance, Neurodivergence, and Gene–Environment Interaction in Complex Chronic IllnessSemantic proximity
Select a neighboring publication to make it the new centre.