Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The origin of complex human diversity: Stochastic epistatic modules and the intrinsic compatibility between distributional robustness and phenotypic changeability

Journal of integrative neuroscience - 15 Feb 2018

Ijichi Shinji, Ijichi Naomi, Ijichi Yukina, Imamura Chikako, Sameshima Hisami, Kawaike Yoichi, Morioka Hirofumi

Abstract excerpt

The continuing prevalence of a highly heritable and hypo-reproductive extreme tail of a human neurobehavioral quantitative diversity suggests the reproductive majority retains the genetic mechanisms for extremes. From the perspective of stochastic epistasis, the effect of an epistatic modifier variant can randomly vary in both phenotypic value and effect direction among carriers depending on the genetic identity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Genetic

Share to Phenotype

Share to Stochastic Processes

Source

Identifiers

PMID: 29376879
DOI: 10.31083/JIN-170034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The origin of complex human diversity: Stochastic epistatic modules and the intrinsic compatibility between distributional robustness and phenotypic changeabilityPMID 29376879Read ↗

Phenotypic heterogeneity in human genetic diseases: ultrasensitivity-mediated threshold effects as a unifying molecular mechanism.Semantic proximity Read ↗

From Peas to Disease: Modifier Genes, Network Resilience, and the Genetics of Health.Semantic proximity Read ↗

Survival of the Curviest: Noise-Driven Selection for Synergistic Epistasis.Semantic proximity Read ↗

[Genome, environment and plasticity of the brain underlying individual adaptation].Semantic proximity Read ↗

Genotypic Context and Epistasis in Individuals and Populations.Semantic proximity Read ↗

A General Model of the Relationship between the Apportionment of Human Genetic Diversity and the Apportionment of Human Phenotypic Diversity.Semantic proximity Read ↗

Mutation and Human Exceptionalism: Our Future Genetic Load.Semantic proximity Read ↗

Origin of the fittest: link between emergent variation and evolutionary change as a critical question in evolutionary biology.Semantic proximity Read ↗

Phenotypic variability: underlying mechanisms and limits do matter.Semantic proximity Read ↗

For others: epistasis and the evolutionary survival of an extreme tail of the quantitative distribution of autistic assets.Semantic proximity Read ↗

The thrifty phenotype as an adaptive maternal effect.Semantic proximity Read ↗

On the universality of human nature and the uniqueness of the individual: the role of genetics and adaptation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.