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Article

Human whole-exome genotype data for Alzheimer's disease.

Nature communications - 23 Jan 2024

Leung Yuk Yee, Naj Adam C, Chou Yi-Fan, Valladares Otto, Schmidt Michael, Hamilton-Nelson Kara, Wheeler Nicholas, Lin Honghuang, Gangadharan Prabhakaran, Qu Liming, Clark Kaylyn, Kuzma Amanda B, Lee Wan-Ping, Cantwell Laura, Nicaretta Heather, Haines Jonathan, Farrer Lindsay, Seshadri Sudha, Brkanac Zoran, Cruchaga Carlos, Pericak-Vance Margaret, Mayeux Richard P, Bush William S, Destefano Anita, Martin Eden, Schellenberg Gerard D, Wang Li-San

Abstract excerpt

The heterogeneity of the whole-exome sequencing (WES) data generation methods present a challenge to a joint analysis. Here we present a bioinformatics strategy for joint-calling 20,504 WES samples collected across nine studies and sequenced using ten capture kits in fourteen sequencing centers in the Alzheimer's Disease Sequencing Project. The joint-genotype called variant-called format (VCF) file contains only...

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PMID: 38263370
DOI: 10.1038/s41467-024-44781-7
PMCID: PMC10805795

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