Article

Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases

2025-09-25

Abstract excerpt

Regulatory T cells (Tregs), characterized by FOXP3 expression, are essential for maintaining immune homeostasis by controlling inflammation. However, in autoimmune diseases such as rheumatoid arthritis (RA), impaired Treg function contributes to immune dysregulation and disease pathology. While most studies of human Tregs have focused on blood, here we analyzed Tregs in synovial tissues from RA patients using sing...

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Literature Corpus work: 8700c963-56a3-5172-a0fc-eb9dae3ff17e
DOI: 10.1101/2025.09.23.677874

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