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Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells

24 Mar 2020

Abstract excerpt

Aging is characterized by a gradual loss of function occurring at the molecular, cellular, tissue and organismal levels. At the chromatin level, aging associates with progressive accumulation of epigenetic errors that eventually lead to aberrant gene regulation, stem cell exhaustion, senescence, and deregulated cell/tissue homeostasis. Nuclear reprogramming to pluripotency can revert both the age and the identity...

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PMID: 32210226
DOI: 10.1038/s41467-020-15174-3

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