Article
Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival.
Blood - 10 Feb 2011
Steinbrunn Torsten, Stühmer Thorsten, Gattenlöhner Stefan, Rosenwald Andreas, Mottok Anja, Unzicker Christian, Einsele Hermann, Chatterjee Manik, Bargou Ralf C
Abstract excerpt
We have recently shown that approximately half of primary multiple myeloma (MM) samples display constitutive Akt activity, which disposes them for sensitivity to Akt inhibition. The Akt pathway counts among the signaling conduits for oncogenic RAS and activating mutations of K- and N-RAS frequently occur in MM. We therefore analyzed the relation between RAS mutation and Akt dependency in biopsies and...
Topics
- Base Sequence
- Cell Line, Tumor
- Cell Survival
- DNA Primers
- Gene Knockdown Techniques
- Genes, ras
- Humans
- MAP Kinase Signaling System
- Multiple Myeloma
- Mutation