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Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates

15 Jul 2020

Abstract excerpt

Integrins are heterodimeric cell surface receptors composed of α and β subunits that control adhesion, proliferation and gene expression. The integrin heterodimer binding to ligand reorganises the cytoskeletal networks and triggers multiple signalling pathways that can cause changes in cell cycle, proliferation, differentiation, survival and motility. In addition, integrins have been identified as targets for...

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PMID: 32679769
DOI: 10.3390/cancers12071910

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