Article
Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration.
PLoS computational biology - 1 Nov 2015
Cohen David P A, Martignetti Loredana, Robine Sylvie, Barillot Emmanuel, Zinovyev Andrei, Calzone Laurence
Abstract excerpt
Understanding the etiology of metastasis is very important in clinical perspective, since it is estimated that metastasis accounts for 90% of cancer patient mortality. Metastasis results from a sequence of multiple steps including invasion and migration. The early stages of metastasis are tightly controlled in normal cells and can be drastically affected by malignant mutations; therefore, they might constitute...
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