Article

Discovery of WS-384, a first-in-class dual LSD1 and DCN1-UBC12 protein-protein interaction inhibitor for the treatment of non-small cell lung cancer (NSCLC)

2023-02-20

Abstract excerpt

<title>Abstract</title> <p>Abnormally high expression of lysine-specific demethylase 1A (LSD1) and DCN1 plays a vital role in the occurrence, development, and poor prognosis of non-small cell lung cancer (NSCLC). Accumulating evidence has shown that the development of small-molecule inhibitors dually targeting LSD1 and the UBC12-DCN1 interaction probably have therapeutic promise for cancer therapy. This work repo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5e68a31-b529-5d30-9c18-b47325e4730b
DOI: 10.21203/rs.3.rs-2593334/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery of WS-384, a first-in-class dual LSD1 and DCN1-UBC12 protein-protein interaction inhibitor for the treatment of non-small cell lung cancer (NSCLC)DOI 10.21203/rs.3.rs-2593334/v1Read

Advances Toward Lsd1 Inhibitors for Cancer TherapySemantic proximity Read

Inhibition of DKC1  Induces Telomere-related Senescence and Apoptosis in Lung Adenocarcinoma Semantic proximity Read

Identifying the Role of NUDCD1 in Human Tumors from Clinical and Molecular MechanismsSemantic proximity Read

MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapySemantic proximity Read

Unraveling the Potential Role of NEDD4-like E3 Ligases in CancerSemantic proximity Read

Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastomaSemantic proximity Read

The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and TherapySemantic proximity Read

Downregulation of NEDD4L by EGFR Signaling Promotes the Development of Lung AdenocarcinomaSemantic proximity Read

Inhibition of CDCP1 by 8-isopentenylnaringenin synergizes with EGFR inhibitors in lung cancer treatment.Semantic proximity Read

NEDD8-conjugating enzyme E2s: critical targets for cancer therapySemantic proximity Read

The Novel LSD1 Inhibitor ZY0511 Suppresses Diffuse Large B Cell Lymphoma Proliferation by Inducing Apoptosis and AutophagySemantic proximity Read

NOTCH1 collaborated with innate immune to regulate genomic instability caused by epigenetic enzyme deletion in cold tumorSemantic proximity Read