Article

NOTCH1 collaborated with innate immune to regulate genomic instability caused by epigenetic enzyme deletion in cold tumor

2024-08-07

Abstract excerpt

<title>Abstract</title> <p>NOTCH1 was unfavorable to tumor immunoinfiltration in cold tumors. Targeting NOTCH1 for effective immunotherapy has been a challenge. Single cell data analysis found NOTCH1 signaling was gradually activated as lung inflammatory disease progressed. We found that NOTCH1 was highly expressed in proliferating airway epithelial cells of Lung squamous cell carcinoma (LUSC) tumor tissues. Data...

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Literature Corpus work: 1a3d2ef4-23de-5fa4-95b4-0c66628a02e4
DOI: 10.21203/rs.3.rs-4702578/v1

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