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Topological Pharmacokinetics: Reading the Shape of Drug Disposition from Data

2026-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Pharmacokinetic analysis has spent half a century compressing drug concentration–time curves into scalar summaries—AUC, C max , clearance—discarding the shape information that encodes mechanistic fingerprints of the underlying physiology. We introduce Topological Pharmacokinetics (TPK), a framework that reads the shape of pharmacokinetic trajectories directly from data without prior commitment...

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Literature Corpus work
d5d46043-df0b-5910-8c33-86f51edd03d5
DOI
10.64898/2026.05.13.724751
Open publication

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Topological Pharmacokinetics: Reading the Shape of Drug Disposition from DataDOI 10.64898/2026.05.13.724751
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