Article

Sim2Real-PK framework for precision dosing: Integrating pharmacokinetic mechanisms and deep learning to decode clinical heterogeneity from sparse data

2026-04-24

Abstract excerpt

<title>Abstract</title> <p>Precision dosing is a cornerstone of individualized therapeutics, yet its implementation is frequently hindered by clinical pharmacokinetic data that are characteristically sparse, irregularly sampled, and highly heterogeneous. Traditional mechanistic models provide structural interpretability but often lack the flexibility to capture complex patient-specific deviations, whereas purely...

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Literature Corpus work: 9ef085c2-f57d-5fe1-b217-b83587d4d854
DOI: 10.21203/rs.3.rs-9308510/v1

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