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Evaluation of the Basis and Performance of Simple Allometry for Predictions of Clearance and Oral Clearance in Humans and Improvement Potential with Added <i>In Silico</i> Predictions and 2D PK-Space Positioning

2025-05-08

Abstract excerpt

<h4> A bstract </h4> <h4>Background</h4> Allometry is traditionally used in drug development in order to extrapolate and predict pharmacokinetic (PK) parameter estimates, such as steady-state volume of distribution (V ss ), clearance (CL), oral clearance (CL/F, where F is the oral bioavailability) in animal species to humans. Recent results show that in silico prediction methodology can improve and outperfor...

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Literature Corpus work
3a58019b-3add-51d3-9587-d51a6318bffe
DOI
10.1101/2025.05.05.652242
Open publication

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Evaluation of the Basis and Performance of Simple Allometry for Predictions of Clearance and Oral Clearance in Humans and Improvement Potential with Added <i>In Silico</i> Predictions and 2D PK-Space PositioningDOI 10.1101/2025.05.05.652242
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