Article

Derivation and theoretical validation of fractional quasi-steady state approximation (fQSSA) for target-mediated drug disposition models with memory effects

2026-04-29

Abstract excerpt

Standard target-mediated drug disposition (TMDD) models are widely used to describe nonlinear pharmacokinetics driven by high-affinity drug–target interactions. However, their reliance on instantaneous binding limits their ability to capture delayed and history-dependent dynamics observed in vivo . Here, we introduce a fractional TMDD model that incorporates memory effects through a fractional derivative, thereby...

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Literature Corpus work: 345dc8aa-a964-5983-9a83-6cd65581a867
DOI: 10.64898/2026.04.27.721025

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Derivation and theoretical validation of fractional quasi-steady state approximation (fQSSA) for target-mediated drug disposition models with memory effectsDOI 10.64898/2026.04.27.721025Read

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