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Gap Junctional Communication Required for the Establishment of Long-Term Robust Ca<sup>2+</sup> Oscillations Across Human Neuronal Spheroids and Extended 2D Cultures

2025-09-24

Abstract excerpt

Synchronized oscillatory fluctuations in intracellular calcium concentration across extended neuronal networks represent a functional indicator of connectivity and signal coordination. In this study, human dopaminergic neurons (LUHMES cell line) have been used to establish a robust protocol for generating reproducible intracellular Ca²⁺ oscillations in both two-dimensional monolayers and three-dimensional spheroid...

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Literature Corpus work
d58c3eba-2c81-5978-af62-82edfc6c892e
DOI
10.20944/preprints202509.1991.v1
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Gap Junctional Communication Required for the Establishment of Long-Term Robust Ca<sup>2+</sup> Oscillations Across Human Neuronal Spheroids and Extended 2D CulturesDOI 10.20944/preprints202509.1991.v1
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