Article

Human Lung Alveolar Model with an Autologous Innate and Adaptive Immune Compartment

2025-02-27

Abstract excerpt

Lung-resident immune cells, spanning both innate and adaptive compartments, preserve the integrity of the respiratory barrier, but become pathogenic if dysregulated 1 . Current in vitro organoid models aim to replicate interactions between the alveolar epithelium and immune cells but have not yet incorporated lung-specific immune cells critical for tissue residency 2 . Here we address this shortcoming by describ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b0a476a6-f062-5af0-96a5-8c6c38d1f434
DOI: 10.1101/2025.02.27.640440

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Lung Alveolar Model with an Autologous Innate and Adaptive Immune CompartmentDOI 10.1101/2025.02.27.640440Read

Organoid modeling of lung-resident immune responses to SARS-CoV-2 infectionSemantic proximity Read

Organoid modeling of lung-resident immune responses to SARS-CoV-2 infectionSemantic proximity Read

A single-cell atlas of in vitro multiculture systems uncovers the in vivo lineage trajectory and cell state in the human lungSemantic proximity Read

Integrated EVLP and single-cell profiling uncovers aberrant activation of tissue-resident lymphocytes and pro-fibrotic GZMK⁺ CD8 T cells in IPFSemantic proximity Read

Human intestinal organoids with an autologous tissue-resident immune compartmentSemantic proximity Read

Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19Semantic proximity Read

A single cell atlas of in vitro multi-systems uncovers in vivo lineage trajectory and cell state in the human lungSemantic proximity Read

Lung Immune Cell Niches and the Discovery of New Cell SubtypesSemantic proximity Read

Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19Semantic proximity Read

Macrophages Mediate Antiviral Immunity and Repair of Type 2 Alveolar Epithelial Cells in a Human Stem Cell ModelSemantic proximity Read

Function-associated scRNA-seq on single lung cancer organoids unravels the immune landscape of tumor parenchymaSemantic proximity Read

BATF promotes group 2 innate lymphoid cell–mediated lung tissue protection during acute respiratory virus infectionSemantic proximity Read