Article

Nanopore-based cell-free DNA fragmentation and methylation profiles from the cerebral spinal fluid of patients with lung cancer brain metastases

2025-07-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Non-small cell lung cancer ( NSCLC ) patients with brain metastases ( BMET ) have a poor prognosis. Cerebrospinal fluid ( CSF ) is a source of cell free DNA ( cfDNA ) from the brain and its methylation and fragmentation properties may be an indicator of NSCLC-BMET. <h4>Methods</h4> We applied a nanopore single-molecule sequencing approach to characterize the fragmentat...

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Literature Corpus work: d56bce83-54ff-54ce-961b-44d03851fbea
DOI: 10.1101/2025.07.28.667300

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