Article

Treatment with mitochondrial targeting antibiotics improves survival outcomes after Flock House virus infection in young and aged Drosophila melanogaster

2025-06-10

Abstract excerpt

<title>Abstract</title> Aged organisms are more susceptible to infectious diseases, including infections with RNA viruses. Mitochondrial dysfunction is one of many hallmarks of aging that could affect this increased susceptibility, as the relationship between immunity and metabolism is crucial to manage infections. Using <italic>Drosophila melanogaster</italic>- Flock House virus (FHV) host-virus interactions...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d53591e3-0730-571c-92e3-f751598c525c
DOI: 10.21203/rs.3.rs-6816306/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Treatment with mitochondrial targeting antibiotics improves survival outcomes after Flock House virus infection in young and aged Drosophila melanogasterDOI 10.21203/rs.3.rs-6816306/v1Read

Age-dependent impairment of disease tolerance is associated with a robust transcriptional response following RNA virus infection in DrosophilaSemantic proximity Read

A naturally occurring mitochondrial genome variant confers broad protection from infection in Drosophila.Semantic proximity Read

Anti-retroviral treatment with zidovudine alters pyrimidine metabolism, reduces translation, and extends healthy longevity via ATF-4Semantic proximity Read

Drosophila as a Model System to Investigate the Effects of Mitochondrial Variation on Innate Immunity.Semantic proximity Read

Mild impairment of mitochondrial function increases longevity and pathogen resistance through ATFS-1-driven activation of p38-regulated innate immunitySemantic proximity Read

Antibiotics Against COVID-19 and Mitochondria? Urgent Thinking Out of the BoxSemantic proximity Read

Dietary fiber supplementation increases Drosophila melanogaster lifespan and gut microbiota diversitySemantic proximity Read

Midgut Mitochondrial Function as a Gatekeeper for Malaria Parasite Infection and Development in the Mosquito HostSemantic proximity Read

Multi-Omics Reprogramming Drives a Counterintuitive Reversal of Disease Susceptibility During AgeingSemantic proximity Read

Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions.Semantic proximity Read

Flock House Virus RNA Replicates on Outer Mitochondrial Membranes in Drosophila CellsSemantic proximity Read

Mitigation of the age-dependent decline in mitochondrial genome integritySemantic proximity Read