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Article

A naturally occurring mitochondrial genome variant confers broad protection from infection in Drosophila.

PLoS genetics - 1 Nov 2024

Salminen Tiina S, Vesala Laura, Basikhina Yuliya, Kutzer Megan, Tuomela Tea, Lucas Ryan, Monteith Katy, Prakash Arun, Tietz Tilman, Vale Pedro F

Abstract excerpt

The role of mitochondria in immunity is increasingly recognized, but it is unclear how variation in mitochondrial DNA (mtDNA) contributes to variable infection outcomes. To quantify the effect of mtDNA variation on humoral and cell-mediated innate immune responses, we utilized a panel of fruit fly Drosophila melanogaster cytoplasmic hybrids (cybrids), where unique mtDNAs (mitotypes) were introgressed into a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39527645
DOI: 10.1371/journal.pgen.1011476
PMCID: PMC11614270

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