Article
Recent advances in managing gastrointestinal stromal tumor
2017-09-14
Abstract excerpt
Constitutive activating mutations in KIT and platelet-derived growth factor receptor α ( PDGFRα ) are heavily involved in the pathobiology of gastrointestinal stromal tumors (GISTs). This disease has served as an effective “proof-of-concept” model for targeting gain-of-function kinase mutations in cancer. This review discusses the current standard of care in terms of pharmacotherapy in the management of localized...
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Identifiers and source
- Literature Corpus work
- d50243db-10f4-51af-874e-f38362c710eb
- DOI
- 10.12688/f1000research.11118.1