Article
New advances in biology and treatment of gastrointestinal stromal tumours (GISTs).
Minerva chirurgica - 1 Jun 2007
Comandone A, Boglione A, Bergnolo P, Berno E
Abstract excerpt
Gastrointestinal stromal tumours (GISTs) are a precise oncogenetic entity that has started the new era of targeted therapies in solid tumours. GISTs are now a model to understand the role of oncogenic kinase mutation in tumourigenesis, duplication, cell regulation, apoptosis and drug resistance. Ninety-five percent of GISTs have some activacting mutation of c-KIT or PDGFRA tyrosine kinase. The studies of the last...
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