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Article

Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2016

Koukouli Fani, Rooy Marie, Changeux Jean-Pierre, Maskos Uwe

Abstract excerpt

The prefrontal cortex (PFC) plays an important role in cognitive processes, including access to consciousness. The PFC receives significant cholinergic innervation and nicotinic acetylcholine receptors (nAChRs) contribute greatly to the effects of acetylcholine signaling. Using in vivo two-photon imaging of both awake and anesthetized mice, we recorded spontaneous, ongoing neuronal activity in layer II/III in the...

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Identifiers

PMID: 27911815
DOI: 10.1073/pnas.1614417113
PMCID: PMC5187677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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