Article

ABC-transporter CFTR folds with high fidelity through a modular, stepwise pathway

2022-07-21

Abstract excerpt

<h4>ABSTRACT</h4> The question how proteins fold is especially pointed for large multidomain, multispanning membrane proteins with complex topologies. We have uncovered the sequence of events that encompass proper folding of the ABC transporter CFTR in live cells, by combining kinetic radiolabeling with protease-susceptibility assays. We found that CFTR folds in two clearly distinct stages. The first, co-translat...

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Literature Corpus work: d4c0d6ae-8f39-524b-8e5e-6653d0711272
DOI: 10.1101/2022.07.20.500765

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