Article

Epigenetics of<i>PNLIPRP1</i>in human pancreas reveals a molecular path between type 2 diabetes and pancreatic cancer

2022-12-30

Abstract excerpt

<h4>Background</h4> Type 2 diabetes (T2D) increases the risk of pancreatic ductal adenocarcinoma (PDAC), which could be due to an epigenetic mechanism. <h4>Methods</h4> We explored the association between T2D and whole pancreas methylation in 141 individuals, of which 28 had T2D, using Illumina MethylationEPIC 850K BeadChip arrays. We performed downstream functional assessment in the rat acinar pancreas cell line...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c49d4dfd-c132-5ed1-be4a-95b21f0a66be
DOI: 10.1101/2022.12.30.22284058

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetics of<i>PNLIPRP1</i>in human pancreas reveals a molecular path between type 2 diabetes and pancreatic cancerDOI 10.1101/2022.12.30.22284058Read

Epigenetic regulation of insulin action and secretion - role in the pathogenesis of type 2 diabetes.Semantic proximity Read

Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes PathogenesisSemantic proximity Read

Elucidating the Epigenetic Landscape of Type 2 Diabetes: A Multi-Omics Analysis Revealing Novel CpG Sites and Their Association with Cardiometabolic TraitsSemantic proximity Read

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin SecretionSemantic proximity Read

Discovery of novel genes and genetic regulatory mechanisms through integrative genomic, epigenetic and transcriptional analysis in human pancreatic islet cellsSemantic proximity Read

DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitusSemantic proximity Read

Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populationsSemantic proximity Read

Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals.Semantic proximity Read

An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signalsSemantic proximity Read

DNA Methylation as a Diagnostic and Therapeutic Target in the Battle Against Type 2 DiabetesSemantic proximity Read

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in developmentSemantic proximity Read

Epigenetic Changes in Islets of Langerhans Preceding the Onset of DiabetesSemantic proximity Read