Article

GuidingNet: revealing transcriptional cofactor and predicting binding for DNA methyltransferase by network regularization

2020-06-02

Abstract excerpt

The DNA methyltransferases (DNMTs) (DNMT3A, DNMT3B, and DNMT3L) are primarily responsible for the establishment of genomic locus-specific DNA methylation patterns, which play an important role in gene regulation and animal development. However, this important protein family’s binding mechanism, i.e., how and where the DNMTs bind to genome, is still missing in most tissues and cell lines. This motivates us to explo...

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Literature Corpus work: d4636d23-d944-5926-b65d-4d91a39f90fc
DOI: 10.1101/2020.06.02.129445

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