Article

GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans

2021-07-05

Abstract excerpt

Chronically elevated intraocular pressure (IOP) is the major risk factor of primary open- angle glaucoma, a leading cause of blindness. Dysfunction of the trabecular meshwork (TM), which controls the outflow of aqueous humor (AqH) from the anterior chamber, is the major cause of elevated IOP. Here, we demonstrate that mice deficient in the Krüppel- like zinc finger transcriptional factor GLI-similar-1 (GLIS1) deve...

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Literature Corpus work: d44b9750-5e59-5891-b638-1a5d0647f42e
DOI: 10.1101/2021.07.02.450719

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