Article

Perilipin 4 repetitive region forms amyloid fibrils promoted by a genetic expansion found in myopathy patients

2025-06-04

Abstract excerpt

Lipid-binding amphipathic proteins play key roles in cellular organization, yet their conformational flexibility makes them prone to aggregation. Here we study the aggregation of perilipin 4 (PLIN4), a protein of the lipid droplet (LD)-binding perilipin family. PLIN4 contains an unusually long (∼1000 amino acid, aa) amphipathic helix composed of tandem 33–aa repeats, which folds on the LD surface. A genetic expans...

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Literature Corpus work: d4282b4d-1d7f-569f-965d-cf9b5c88a246
DOI: 10.1101/2025.06.03.657256

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