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Article

Cardiomyopathy-associated and basic residue mutations in myopalladin alter actin binding, bundling, and structural stability.

Protein science : a publication of the Protein Society - 1 Feb 2026

Arachchige Asha Rankoth, Tran Julie, Zhao Ziwei, Dammann Hannah, Michaelis Alia, Kadarla Vinay K, Zolkiewski Michal, Geisbrecht Erika R, Beck Moriah R

Abstract excerpt

Myopalladin (MYPN) is a striated muscle-specific protein essential for sarcomere integrity and actin filament organization. The Ig3 domain of MYPN mediates direct binding and bundling of filamentous actin (F-actin), and several cardiomyopathy (CM)-associated mutations cluster within this domain. To elucidate the molecular basis of MYPN-actin interactions, we performed alanine-scanning mutagenesis of conserved...

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Identifiers

PMID: 41578973
DOI: 10.1002/pro.70490
PMCID: PMC12831284

Genes

MYPN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Cardiomyopathy-associated and basic residue mutations in myopalladin alter actin binding, bundling, and structural stability.PMID 41578973Read ↗

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